ID-IRC : 2413040927
DRIOWYA Mohsine
Professeur d’habilité
Spécialité : Chimie
École Supérieure de Technologie de Khénifra
Faculté des sciences de Rabat
Domaine de Maîtrise :
Recherche Clinique
Domaine d’intérêt :
Épidémiologie et Santé Publique, Essais Cliniques, Recherche Clinique
Les publications :
• Zerhouni, M., …, Driowya, M., et al. Dual Covalent Inhibition of PKM and IMPDH Targets Metabolism in Cutaneous Metastatic Melanoma, Cancer Res 2021, 81, 3806-3821.
• Driowya, M. et al. In vitro and in vivo evaluation of fully substituted (5–(3-ethoxy-3-oxopropynyl)-4-(ethoxycarbonyl)-1,2,3-triazolyl-glycosides as original nucleoside analogs to circumvent resistance in myeloid malignancies. Journal of Medicinal Chemistry 2017, 60, 1523-1533.
• Driowya, M.; Allaoui, S.; Dufies, M.; Demange, L.; Bougrin, K.; Robert, G.; Auberger, P.; Pagès, G.; Benhida, R. Synthesis and anti-cancer activities of new sulfonamides 4-substituted-1,2,3triazolyl-nucleosides. Bioorganic & Medicinal Chemistry Letters 2017, 27, 1989-1992.
• Dubois, A, Ginet, C.; Furstoss, N.; Belaid, A.; Hamouda, A.; El Manaa, W.; Cluzeau, T.; Marchetti, S.; Ricci, J.E.; Jacquel, A.; Luciano, F.; Driowya, M.; Benhida, R.; Auberger, P.; Robert, G. Differentiation inducing factor 3 mediates its anti-leukemic effect through ROS-dependent DRP1-mediated mitochondrial fission and induction of caspase-independent cell death. Oncotarget 2016, 7, 26120-26136.
• Driowya, M.; Leclercq, J.; Verones, V.; Barczyk, A.; Lecoeur, M.; Renault, N.; Flouquet, N.; Ghinet, A.; Berthelot, P.; Lebegue, N. Synthesis of triazoloquinazolinone based compounds as tubulin polymerization inhibitors and vascular disrupting agents. Eur. J. Med. Chem. 2016, 115, 393-405.
• Driowya, M.; Puissant, A.; Robert, G.; Auberger, P.; Benhida, R.; Bougrin, K. Ultrasound-assisted iron-copper catalyzed one-pot synthesis of anti-CML nucleosides featuring 1,2,3-triazole nucleobase. Ultrasonics Sonochemistry 2012, 19, 1132-1138.
• Benhida, R.; Auberger, P.; Driowya, M.; Malnuit, V.; Puissant, A.; Robert, G. patent WO2012/143624 A2 (EP 2699240 A2). « Acadesine derivatives, products and compositions including same, therapeutic uses thereof, and methods for synthesizing same ».