Domaine de Maîtrise :
Biopathologie et Recherche Biomédicale

Domaine d’intérêt :
Épidémiologie et Santé Publique, Biopathologie et Recherche Biomédicale**, Nouvelles Technologies - Ingénierie - Systèmes d’Information et IA

Les publications :
1. Kaanane H, Senhaji N, Berradi H, Benchakroun N, Benider A, Karkouri M, El Attar H, IGOT CASA, Khyatti M, Nadifi S. Association of Variants in IL6 Related Genes with Lung Cancer Risk in Moroccan Population Lung 197(6), 2019. 2. Kaanane H, Senhaji N, Berradi H, Benchakroun N, Benider A, Karkouri M, El Attar H, Khyatti M, Nadifi S. Association of Inflammation Related Genes with Lung Cancer Risk in Moroccan Population. Journal of Thoracic Oncology, October 2019 Volume 14, Issue 10, Page S719 3. Houda KAANANE, Hicham EL ATTAR, Amal LOUAHABBI, IGOT CASA, Hind BERRADI, Hind HASSANI IDRISSI, Meriem KHYATTI, Sellama NADIFI, Epidermal Growth Factor Receptor Mutational Profile in Lung Cancer Moroccan Cohort. Frontiers in Science and Engineering - Vol. 8 - Supplement 2 – 2019, 79-88. 4. Mohammed EL MZIBRI, Imane CHAOUI, Meriem KHYATTI and Mohammed ATTALEB. The Molecular Basis of Viro-Induced Carcinogenesis. Frontiers in Science and Engineering - Vol. 8 - Supplement 2 – 2019, 39-52. 5. Hajar REHIOUI, Abdellah IDRISSI, Abderrafiaa KOUKAM, Amina GIHBID, Nezha TAWFIQ, Meriem KHYATTI. On the Use of Clustering Algorithms in Medical Domain. International Journal of Artificial Intelligence. 17(2):236, 2019 6. Wafa Khaali, Amina Gihbid, Amal ElAmrani, Imane Chaoui, Mohammed Attaleb, Mustapha Benhassou, Khalid Belghmi, Mohammed El Mzibri, Meriem Khyatti, Prevalence, Genotype Distribution and Risk Factors of Human Papillomavirus in Moroccan Women. Arch Clin Biomed Res 2019; 3 (6). 7. Kaanane H, El Attar H, Louahabi A; IGOT CASA, Berradi H, Idrissi HH, Khyatti M, Nadifi S. Targeted methods for molecular characterization of EGFR mutational profile in lung cancer Moroccan cohort., Gene. 2019 Jul 15;705:36-43. 8. Jankovic R, J Goncalves H, Cavic M, Clemente C, Lind M, Murillo Carrasco A, Nadifi S, Khyatti M, Adebambo T, Egamberdiev D. LungCARD - Report on worldwide research and clinical practices related to lung cancer. J BUON. 2019 Jan-Feb;24(1):11-19. 9. Moumad K, Khaali W, Benider A, Ben Ayoub W, Hamdi-Cherif M, Boualga K, Hassen E, Ben Driss EK, Corbex M, Khyatti M. Joint effect of smoking and NQO1 C609T polymorphism on undifferentiated nasopharyngeal carcinoma risk in a North African population. Mol Genet Genomic Med. 2018 Nov;6(6):933-940. 10. ElAmrani A, Gheit T, Benhessou M, McKay-Chopin S, Attaleb M, Sahraoui S, El Mzibri M, Corbex M, Tommasino M, Khyatti M. Prevalence of mucosal and cutaneous human papillomavirus in Moroccan breast cancer. Papillomavirus Res. 2018 Jun;5:150-155. 11. H. Kaanane, H. El Atar, L. Badre, A. Louahabi, H. Berradi, M. Khyatti,S. Nadifi Identification of EGFR Mutational Profile in Lung Cancer Moroccan Cohort Journal of Thoracic Oncology Journal of Thoracic Oncology, Volume 13, Issue 10, Supplement, October 2018, Page s886 12. M. EL MZIBRI, Imane CHAOUI, Meriem KHYATTI and Mohammed ATTALEB, The Molecular Basis of Viro-Induced Carcinogenesis
 Frontiers in science and engineering International Journal, volume 8, Supplement 2, 2018, pp 39 13. Houda KAANANE, Hicham EL ATTAR, Amal LOUAHABBI, IGOT CASA, Hind BERRADI, Hind HASSANI IDRISSI, Meriem KHYATTI, Sellama NADIFI, Epidermal Growth Factor Receptor Mutational Profile in Lung Cancer Moroccan Cohort 
 Frontiers in science and engineering International Journal, volume 8, Supplement 2, 2018, pp 79 14. Mohamed Hussein W, Anwar W, Attaleb M, Mazini L, Försti A, Trimbitas RD, Khyatti M. A review of the infection-associated cancers in North African countries, Infectious Agents and Cancer 11(1) 2016. 15. Gualdi-Russo E, Rinaldo N, Khyatti M, Lakhoua C, Toselli S, Weight status, fatness and body image perception of North African immigrant women in Italy, Public Health Nutrition -1:1-9·April 2016. 16. Trimbitas R, Fayssel N, Serghini FZ, Wakrim L, Khyatti M, Essalhi M, Bellefquih AM, Benani A. Molecular characterization of hepatitis C virus core region in Moroccan intravenous drug users. J Med Virol DOI 10.1002, 2016. 17. Khaali, Moumad, Ben Driss, Benider, Ben Ayoub, Hamdi-Cherif, Boualga, Hassen, Corbex and Khyatti. No association between TGF-β1 polymorphisms and risk of nasopharyngeal carcinoma in a large North African case-control study. BMC Medical Genetics (2016) 17:72 18. Khaali, Juliette Thariat, Laurence Fantin, Flavia Spirito M. Khyatti, El Khalil Ben Driss Sylvain Olivero, Janet Maryanski, Alain Doglio Expansion of EBNA1- and LMP2-specific effector T lymphocytes from patients with nasopharyngeal carcinoma without enhancement of regulatory T cells. Conference abstract published in 
 BMC Proceedings 2016, Volume 10 Suppl 1. 19. C. Yin, A Foussadier, E Blein, C Chen, N Bournet Ammour, M Khyatti,
S Cao . New prototype Vidas EBV IgA quick: performance on Chinese and Moroccan populations. Conference abstract published in
 BMC Proceedings 2016, Volume 10 Suppl 1. 20. Khaali, Juliette Thariat, Laurence Fantin, Flavia Spirito M. Khyatti, El Khalil Ben Driss Sylvain Olivero, Janet Maryanski, Alain Doglio Expansion of EBNA1- and LMP2-specific effector T lymphocytes from patients with nasopharyngeal carcinoma without enhancement of regulatory T cells. Conference abstract published in 
 BMC Proceedings 2016, Volume 10 Suppl 1. 21. C. Yin, A Foussadier, E Blein, C Chen, N Bournet Ammour, M Khyatti,
S Cao . New prototype Vidas EBV IgA quick: performance on Chinese and Moroccan populations. Conference abstract published in
 BMC Proceedings 2016, Volume 10 Suppl 1. 22. Khyatti M., Zouheir Y., Mohamed W., Trimbitas RD, Attaleb M, Hemminki K, Anwar W. Most salient communicable diseases in North Africa. Annali online dell’Università degli Studi di Ferrara 01/2015; 10(9):159-190. 23. Wagida Anwar, Dalia Sos, Karima Bendahhou, Abdellatif Benider, Amal S. Ibrahim, Kari Hemminki, M Khyatti . Establishment of Cancer Registries in Egypt and Morocco: Prevalent Cancers in both Countries. Lessons on Health and Immigration in Europe: Annali online dell’Università degli Studi di Ferrara. 01/2015; 10(9): 139-158. 24. Nawz, I, Moumad K, Martorelli D, Ennaji MM, Zhou X, Zhang Z, Dolcetti R, Khyatti M, Ernberg I & Hu LF, Detection of nasopharyngeal carcinoma in Morocco (North Africa) using a multiplex methylation-specific PCR biomarker assay. Clin Epigenetics. 2015; 7(1): 89. 25. Ouardy, Benhassou, Khyatti, Mazini, Human Umbilical Cord Blood Mesenchymal Stem Cell Differentiation to Endothelial Progenitor Cells in vitro Results in a Population with an Endothelial and Monocytic Profile, ISESCO JOURNAL of Science and Technology Volume 11 - Number 19 - May 2015 (2-8). 26. Ennaji Moulay Mustapha, Amal ElAmrani , Khyatti Meriem, Benhassou Mustapha, Attalleb Mohamed. Cancer du sein : génétique, facteurs de risque et étiologie virale. éditions universitaires européennes. Livre: 2015. ISBN 978-3-8416-6098-5. 27. Berrada, Amzazi, Abbar,Ameur, Khyatti, Al-Bouzidi and Attaleb M. Mutational Analysis of FGFR3 and HRAS Genes in Bladder Cancer and Washing Cell Sediments of Moroccan Patients. Epidemiology 2015, 5(4):1000214. 28. Elamrani A, Moumad, Attaleb, Benhassou, Försti, Ennaji, El Mzibri, Khyatti. Absence of CHEK21100delC, R145W and I157T mutations in breast cancer in a Moroccan population. Journal of Cancer Research and Treatment, 2014 2 (1), pp 6-9. 29. Mazini L, Matar N, Bouhya S, Marzouk D, Anwar W, Khyatti M. Umbilical Cord Blood Banking for Transplantation in Morocco: Problems and opportunities. Journal of Stem cells and regenerative medicine 10(2):28-37. 2014. 30. Hemminki K, Försti A, Khyatti M, Anwar WA, Mousavi M. Cancer in immigrants as a pointer to the causes of cancer. Eur J Public Health. 2014 Aug;24 Suppl 1:64-71. 31. Anwar WA, Khyatti M, Hemminki K. Consanguinity and genetic diseases in North Africa and immigrants to Europe. Eur J Public Health. 2014 Aug;24 Suppl 1:57-63. 32. Khyatti M, Trimbitas RD, Zouheir Y, Benani A, El Messaoudi MD, Hemminki K. Infectious diseases in North Africa and North African immigrants to Europe. Eur J Public Health. 2014 Aug;24 Suppl 1:47-56. 33. Marzouk D, Abd El Aal W, Saleh A, Sleem H, Khyatti M, Mazini L, Hemminki K, Anwar WA. Overview on health research ethics in Egypt and North Africa. Eur J Public Health. 2014 Aug;24 Suppl 1:87-91. 34. Gualdi-Russo E, Zaccagni L, Manzon VS, Masotti S, Rinaldo N, Khyatti M. Obesity and physical activity in children of immigrants. Eur J Public Health. 2014 Aug;24 Suppl 1:40-6 35. Toselli S, Gualdi-Russo E, Boulos DN, Anwar WA, Lakhoua C, Jaouadi I, Khyatti M, Hemminki K. Prevalence of overweight and obesity in adults from North Africa. Eur J Public Health. 2014 Aug;24 Suppl 1:31-9. 36. Kassar H, Marzouk D, Anwar WA, Lakhoua C, Hemminki K, Khyatti M. Emigration flows from North Africa to Europe. Eur J Public Health. 2014 Aug;24 Suppl 1:2-5. 37. Miri L, Wakrim L, Kassar H, Hemminki K, Khyatti M. Impact of Immigration on HIV-1 molecular epidemiology in West Africa, Maghreb and Southern Europe. AIDS Rev. 2014 Apr-Jun;16(2):109-16. 38. ElAmrani A, M.Khyatti, M.Attalleb, M.Benhassou, M.M. Ennaji, Breast Cancer: Current Datas. Sciencelib Editions Mersenne Volume 5, N° 131124 ISSN 2111-4706. Publié le 26-11-2013. 39. Qmichou Z, Khyatti M, Berraho M, Ennaji MM, Benbacer L, Nejjari C, Benjaafar N, Benider A, Attaleb M, El Mzibri M. Analysis of mutations in the E6 oncogene of human papillomavirus 16 in cervical cancer isolates from Moroccan women. BMC Infect Dis. 2013 Aug 16;13(1):378. 40. ElAmrani A., M.M. Ennaji M.Benhassou, M.Attalleb, M.Mzibri, M.Corbex, T.Massimo, T.Gheit, Khyatti. Detection of human papillomavirus DNA in breast cancer in moroccan woman. Conference abstract published in Annals of Oncology 2013. doi: 10.1093/annonc/mdt086.12. 41. Qmichou, Ennaji, Amrani, El Fahime, Melloul, Meftah El khair, El Mzibri, Khyatti and Attaleb, Molecular Characterization of HPV16 E6 and E7 Variants among Women with Cervical Cancer in Morocco. British Microbiology Research Journal 3(4): 692-705, 2013. 42. Berrada, Amzazi, Ameziane-El-Hassani, Benbacer, Abbar, Al-Bouzidi, Khyatti, El-Mzibri, Ameur, Attaleb. No evidence of correlation between p53 codon 72 polymorphism and risk of bladder cancer in Moroccan patients. Clinical Cancer Investigation Journal 2013, Vol 2, 302-306. 43. Moumad, Lascorz, Bevier, Khyatti, Ennaji, Benider, Huhn, Lu, Chouchane, Corbex, Hemminki, Försti, Genetic Polymorphisms in Host Innate Immune Sensor Genes and the Risk of Nasopharyngeal Carcinoma in North Africa. Genes, Genomes, Genetics (G3) (Bethesda). 2013 Jun 21;3(6):971-7. 44. Berrada, Al-Bouzidi, Ameur, Abbar, El-Mzibri, Ameziane-El-Hassani, Benbacer, Khyatti, Qmichou, Amzazi, Attaleb, Human papillomavirus detection in Moroccan patients with Bladder cancer, J Infect Dev Ctries. 2013 Aug 15;7(8):586-92. 45. Mohammed El Mzibri, Mohammed Attaleb, Rabii Ameziane El Hassani, Meriem Khyatti, Laila Benbacer, My Mustapha Ennaji and Mariam Amrani, Titre du chapitre: "Evaluation of P53, p16INK4a and E-Cadherin Status as Biomarkers for Cervical Cancer Diagnosis". Titre du Livre: "Cervical Cancer with an Advocacy for Prevention" edited by Rajamanickam Rajkumar, ISBN 978-953-51-0183-3, pp 195-214, InTech, March 3, 2012. 46. Khalid Moumad, Nadia Laantri, Mohammed Attaleb, R'Kia Dardari, Nadia Benchakroun, My Mustapha Ennaji and Meriem Khyatti. Titre du chapitre: "Role of the Epstein-Barr virus ZEBRA protein and HPV in the carcinogenesis and diagnostic of Nasopharyngeal carcinoma" in the book: "Carcinogenesis, Diagnosis, and Molecular Targeted Treatment for Nasopharyngeal Carcinoma" Edited by Dr. Shih-Shun Chen, ISBN 978-953-307-867-0, pp 43-60, InTech, February 2, 2012. 47. Berrada N, Amzazi S, Ameziane El Hassani R, Benbacer L, El Mzibri M, Khyatti M, Chafiki J, Abbar M, Al Bouzidi A, Ameur A, Attaleb M.Epigenetic alterations of adenomatous polyposis coli (APC), retinoic acid receptor (RARβ) and survivin genes in tumor tissues and voided urine of bladder cancer patients. Cell. Mol. Biol. 58 (Supp): OL1744-OL1751, 2012. 48. Laantri N, Jalbout M, Khyatti M, Ayoub WB, Dahmoul S, Ayad M, Bedadra W, Abdoun M, Mesli S, Kandil M, Hamdi-Cherif M, Boualga K, Bouaouina N, Chouchane L, Benider A, Ben-Ayed F, Goldgar D, Corbex M. XRCC1 and hOGG1 genes and Risk of Nasopharyngeal Carcinoma in North African Countries," Molecular Carcinogenesis. Sep;50(9):732-7, 2011. 49. Laantri N, Attaleb M, Kandil M, Naji F, Mouttaki T, Dardari R, Belghmi K, Benchakroun N, El Mzibri M, Khyatti M. Human Papillomavirus Detection in Moroccan Patients with Nasopharyngeal Carcinoma. Infectious Agent and Cancer. Feb 25;6(1):3-6, 2011. 50. Laantri, Corbex, Dardari, Benider, El Gueddari, Khyatti Environmental, genetic and viral risk factors of nasopharyngeal carcinoma in North Africa, Biomed Central Proceedings, 5(Suppl 1):P30, 2011. 51. Naji F, Attaleb M, Laantri N, Benchakroun N, El Gueddari B, Benider A, Azeddoug H, Ennaji MM, El Mzibri M, Khyatti M. Identification of G2607A mutation in EGFR gene with a significative rate in moroccan patients with nasopharyngeal carcinoma. Cellular and Molecular Biology. Dec 15;56 1442-6, 2010. 52. El Hamdani W, Amrani M, Attaleb M, Laantri N, Ennaji MM, Khyatti M, El Mzibri M. EGFR, p16INK4a and E-cadherin immuno-histochemistry and EGFR point mutations analyses in invasive cervical cancer specimens from Moroccan women. Cellular and Molecular Biology. Sep 11;56, 1373-1384, 2010. 53. Laantri N, Corbex M, Dardari R, Benider A, El Gueddari B, Khyatti M. Epidemiological, genetic and immuno-virological peculiarities of nasopharyngeal carcinoma in North Africa. Eurocancer 2010, John Libbey eurotext, Paris, pp 127-128, 2010. 54. Attaleb M, El Hamadani W, Khyatti M, Benbacer L, Benchekroun N, Benider A, Amrani M, and El Mzibri M, Status of p16INK4a and E-Cadherin Gene Promoter Methylation in Moroccan Patients With Cervical Carcinoma, Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Vol. 18, pp,1-10, 2009. 55. Feng BJ, Khyatti M, Ben-Ayoub W, Dahmoul S, Ayad M, Maachi F, Bedadra W, Abdoun M, Mesli S, Bakkali H, Jalbout M, Hamdi-Cherif M, Boualga K, Bouaouina N, Chouchane L, Benider A, Ben-Ayed F, Goldgar DE, Corbex M. Cannabis, Tobacco and domestic fumes intake are associated with nasopharyngeal carcinoma in North Africa. British Journal of Cancer. 6;101(7):1207-12, 2009. 56. Dardari R, Menezes J, Drouet E, Joab I, Benider A, Bakkali H, Kanouni L, Jouhadi H, Benjaafar N, Gueddari BE, Hassar M, Khyatti M. Analyses of the prognostic significance of the Epstein-Barr virus transactivator ZEBRA protein and diagnostic value of its two synthetic peptides in nasopharyngeal carcinoma. Journal of Clinical Virology. 2008;41(2):96-103, 2008. 57. Feng BJ, Jalbout M, Ayoub WB, Khyatti M, Dahmoul S, Ayad M, Maachi F, Bedadra W, Abdoun M, Mesli S, Hamdi-Cherif M, Boualga K, Bouaouina N, Chouchane L, Benider A, Ben Ayed F, Goldgar D, Corbex M. Dietary risk factors for nasopharyngeal carcinoma in Maghrebian countries. International Journal of Cancer. 1;121(7):1550-5, 2007. 58. Dardari, R., M. Khyatti, P. Cordeiro, M. Odda, B. El Gueddari, M. Hassar and J. Menezes. High frequency of latent membrane protein 1 30pb-del variants with specific single mutations in Epstein-Barr virus associated nasopharyngeal carcinoma. International Journal of Cancer. 118, 1977–1983, 2006. 59. Dardari, R., W. Hinderer, D. Lang, A. Benider, B. El Gueddari, I. Joab, A. Benslimane and M. Khyatti. Antibody responses to recombinant Epstein-Barr virus antigens in nasopharyngeal carcinoma patients: complementary test of Zebra protein and early antigens p54 and p138. Journal of Clinical Microbiology, 39 (9): 3164-3170, 2001. 60. Dardari, R., M. Khyatti, H. Jouhadi, A. Benider, H. Ettayebi, A. Kahlain, A. Mansouri, B. El Gueddari and A. Benslimane. Study of human leukocyte antigen class I phenotypes in Moroccan patients with nasopharyngeal carcinoma. International Journal of Cancer. 92(2): 294-297, 2001.
 61. Dardari, R., M. Khyatti, A. Benider, H. Jouhadi, A. Kahlain, C. Cochet, A. Mansouri, B. El Gueddari, A. Benslimane and I. Joab. Antibodies to the Epstein-Barr virus transactivator protein (ZEBRA) as a valuable biomarker in young patients with nasopharyngeal carcinoma. International Journal of Cancer. 86(1): 71-75, 2000. 62. Khyatti, M., A. Ahmad, M. Blagdon, R. Frade and J. Menezes. Binding of the endogenously expressed Epstein-Barr virus (EBV) envelope glycoprotein gp350 with the viral receptor masks the major EBV- neutralizing epitope and affects gp350-specific ADCC. Journal of Leukocyte Biology. 64(2): 192- 197, 1998. 63. Khyatti, M., I. Stefanescu and J. Menezes. Evidence for interleukin-2 (IL-2)-mediated control of EBV infected/transformed cells: effect exerted through effector cells with dual CD8+/CD16+ phenotype. Dans: “Epstein-Barr Virus and Associated Diseases”. (T. Turs,z J.S. Pagano, D.V. Ablasi, G. de Thé, G. Lenoir and G.P. Pearson, eds.). INSERM/John Libbey Eurotext Ltd, vol. 225, pp. 325-332, 1993. 64. Khyatti, M., I. Stefanescu, M. Blagdon and J. Menezes. Epstein-Barr virus gp350-specific antibody titers and antibody-dependent cellular cytotoxic effector function in different groups of patients: A study using cloned gp350-expressing transfected human T cell targets. The Journal of Infectious Diseases. 170: 1439- 1447, 1994. 65. Khyatti, M, P. Patel and J. Menezes. Establishment and characterization of Epstein-Barr virus gp350- expressing transfected human lymphoid (Raji) cell clones. International Journal of Cancer. 48: 591- 597, 1991. 66. Khyatti, M., P. Patel, I. Stefanescu and J. Menezes. Epstein-Barr virus (EBV) glycoprotein gp350 expressed on transfected cells resistant to natural killer cell activity serves as a target antigen for EBV- specific antibody-dependent cellular cytotoxicity. Journal of Virology. 65: 996-1001, 1991. 67. Khyatti, M and J. Menezes. The effect of Indomethacin, Prostaglandin E2 and Interferon on the multiplication of herpes simplex virus type 1 in human lymphoid cells. Antiviral Research. 14: 161-172, 1990. 68. Khyatti, M, P. Patel and J. Menezes. Role of the Epstein-Barr virus (EBV) glycoprotein gp350 as a target antigen for EBV-specific cellular killing. Dans: “Epstein-Barr Virus and Human Disease”. (D.V. Ablashi, A.T. Huang, J.S. Pagano, G.R. Pearson, and C.S. Yang eds.). Humana Press Inc. Clifton, N.J. pp. 201-206, 1990.