Domaine de Maîtrise :
Biopathologie et Recherche Biomédicale

Domaine d’intérêt :
Recherche Clinique, Biopathologie et Recherche Biomédicale**

Les publications :
1: Colin L, Dekoninck A, Reichert M, Calao M, Merimi M, Van den Broeke A, Vierendeel V, Cleuter Y, Burny A, Rohr O, Van Lint C. Chromatin disruption in the promoter of bovine leukemia virus during transcriptional activation. Nucleic Acids Res. 2011 Dec;39(22):9559-73. doi: 10.1093/nar/gkr671. Epub 2011 Sep 2. PubMed PMID: 21890901; PubMed Central PMCID: PMC3239207. 2: Merimi M, Ozkan Y, Cleuter Y, Griebel P, Burny A, Martiat P, Van den Broeke A. Epigenetics and leukemia: unraveling oncogenic processes in the BLV ovine model. Front Biosci (Schol Ed). 2009 Jun 1;1:154-63. Review. PubMed PMID: 19482691. 3: Akl H, Badran B, Dobirta G, Manfouo-Foutsop G, Moschitta M, Merimi M, Burny A, Martiat P, Willard-Gallo KE. Progressive loss of CD3 expression after HTLV-I infection results from chromatin remodeling affecting all the CD3 genes and persists despite early viral genes silencing. Virol J. 2007 Sep 6;4:85. PubMed PMID: 17822534; PubMed Central PMCID: PMC2042505. 4: Merimi M, Klener P, Szynal M, Cleuter Y, Bagnis C, Kerkhofs P, Burny A, Martiat P, Van den Broeke A. Complete suppression of viral gene expression is associated with the onset and progression of lymphoid malignancy: observations in Bovine Leukemia Virus-infected sheep. Retrovirology. 2007 Jul 23;4:51. PubMed PMID: 17645797; PubMed Central PMCID: PMC1948017. 5: Merimi M, Klener P, Szynal M, Cleuter Y, Kerkhofs P, Burny A, Martiat P, Van den Broeke A. Suppression of viral gene expression in bovine leukemia virus-associated B-cell malignancy: interplay of epigenetic modifications leading to chromatin with a repressive histone code. J Virol. 2007 Jun;81(11):5929-39. Epub 2007 Mar 28. PubMed PMID: 17392371; PubMed Central PMCID: PMC1900279. 6: Klener P, Szynal M, Cleuter Y, Merimi M, Duvillier H, Lallemand F, Bagnis C, Griebel P, Sotiriou C, Burny A, Martiat P, Van den Broeke A. Insights into gene expression changes impacting B-cell transformation: cross-species microarray analysis of bovine leukemia virus tax-responsive genes in ovine B cells. J Virol. 2006 Feb;80(4):1922-38. PubMed PMID: 16439548; PubMed Central PMCID: PMC1367148. 7: Rouas R, Merimi M, Najar M, El Zein N, Fayyad-Kazan M, Berehab M, Agha D, Bron D, Burny A, Rachidi W, Badran B, Lewalle P, Fayyad-Kazan H. Human CD8(+) CD25 (+) CD127 (low) regulatory T cells: microRNA signature and impact on TGF-β and IL-10 expression. J Cell Physiol. 2019 Aug;234(10):17459-17472. doi: 10.1002/jcp.28367. Epub 2019 Feb 25. PubMed PMID: 30805923. 8: Najar M, Bouhtit F, Melki R, Afif H, Hamal A, Fahmi H, Merimi M, Lagneaux L. Mesenchymal Stromal Cell-Based Therapy: New Perspectives and Challenges. J Clin Med. 2019 May 8;8(5). pii: E626. doi: 10.3390/jcm8050626. PubMed PMID: 31071990; PubMed Central PMCID: PMC6572531. 9: Bouhtit F, Najar M, Agha DM, Melki R, Najimi M, Sadki K, Lewalle P, Hamal A, Lagneaux L, Merimi M. The biological response of mesenchymal stromal cells to thymol and carvacrol in comparison to their essential oil: An innovative new study. Food Chem Toxicol. 2019 Dec;134:110844. doi: 10.1016/j.fct.2019.110844. Epub 2019 Sep 25. PubMed PMID: 31562950. 10: Najar M, Lombard CA, Fayyad-Kazan H, Faour WH, Merimi M, Sokal EM, Lagneaux L, Fahmi H. Th17 immune response to adipose tissue-derived mesenchymal stromal cells. J Cell Physiol. 2019 Nov;234(11):21145-21152. doi: 10.1002/jcp.28717. Epub 2019 Apr 30. PubMed PMID: 31041809. 11: Najar M, Ouhaddi Y, Bouhtit F, Melki R, Afif H, Boukhatem N, Merimi M, Fahmi H. Empowering the immune fate of bone marrow mesenchymal stromal cells: gene and protein changes. Inflamm Res. 2019 Feb;68(2):167-176. doi: 10.1007/s00011-018-1198-8. Epub 2018 Nov 14. PubMed PMID: 30426152. 12: Pierard V, Guiguen A, Colin L, Wijmeersch G, Vanhulle C, Van Driessche B, Dekoninck A, Blazkova J, Cardona C, Merimi M, Vierendeel V, Calomme C, Nguyên TL, Nuttinck M, Twizere JC, Kettmann R, Portetelle D, Burny A, Hirsch I, Rohr O, Van Lint C. DNA cytosine methylation in the bovine leukemia virus promoter is associated with latency in a lymphoma-derived B-cell line: potential involvement of direct inhibition of cAMP-responsive element (CRE)-binding protein/CRE modulator/activation transcription factor binding. J Biol Chem. 2010 Jun 18;285(25):19434-49. doi: 10.1074/jbc.M110.107607. Epub 2010 Apr 22. PubMed PMID: 20413592; PubMed Central PMCID: PMC2885223. 13: Fayyad-Kazan H, Rouas R, Merimi M, El Zein N, Lewalle P, Jebbawi F, Mourtada M, Badran H, Ezzeddine M, Salaun B, Romero P, Burny A, Martiat P, Badran B. Valproate treatment of human cord blood CD4-positive effector T cells confers on them the molecular profile (microRNA signature and FOXP3 expression) of natural regulatory CD4-positive cells through inhibition of histone deacetylase. J Biol Chem. 2010 Jul 2;285(27):20481-91. doi: 10.1074/jbc.M110.119628. Epub 2010 Apr 28. Erratum in: J Biol Chem. 2011 Feb 18;286(7):5934. J Biol Chem. ;286(7):5934. PubMed PMID: 20427269; PubMed Central PMCID: PMC2898312.